Formulation—integration of known and novel technologies to deliver stable
peptides through oral, subcutaneous, and other dosage forms to exploit the intrinsic stability of our drug candidates for optimizing
treatment options for patients. This can enable systemic and local delivery to tissues and organs of choice.
Medicinal, computational, and structural peptide chemistry—allows optimization and
refinement of potency, selectivity, oral and plasma stability, systemic and local bioactivity.
In vivo and ex vivo pharmacology studies, including local (e.g. GI) restriction—involving tools to
simulate pathophysiology for determination of compound concentrations, metabolism and activity in various GI tissue compartments and feces
to develop oral products with GI stability and maximal local and or systemic exposure as desired.