Oral peptides with dual mu/delta opioid receptor agonist activities are superior to eluxadoline in preclinical models of IBS-D

Larry Mattheakis, Li Zhao, Noa Zerangue, Heather Hsu, Jenny Zhang, Greg Bourne, Adam Stephenson, Ashok Bhandari, David Liu, Sampath-Kumar Anandan, 3rd Meeting of the Federation of Neurogastroenterology and Motility, August 29-September 1, 2018, Amsterdam, Netherlands.

Orally Delivered Peptides for Treatment of Inflammatory Bowel Disease

Smythe, M. L, In: Samuel Chackalamannil, David P Rotella and Simon E Ward, (eds.), (2017), Comprehensive Medicinal Chemistry III vol. 6, pp. 157–170. Oxford: Elsevier. View Page

Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23

Barkan, D.T., Cheng, X-L., Celino, H., Tran, T.T., Bhandari, A., Craik, C.S., Sali, A., and Smythe, M.L., BMC Bioinformatics, (2016), 17, 481. View Page

Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo

Ranganath, S., Bhandari, A., Avitahl-Curtis, N., McMahon, J., Wachtel, D., Zhang J., Leitheiser C., Bernier, S.G., Liu, G., Tran, T.T., Celino, H., Tobin J., Jung, J., Zhao, H., Gle, K.E., Graul, C., Griffin, A., Schairer, W.C., Higgins, C., Reza, T.L., Mowe, E., Rivers, S., Scott, S., Monreal, A., Shea, C., Bourne, G., Coons, C., Smith, A., Tang, K., Mandyam, R.A., Masferer, J., Liu, D., Patel, D.V., Fretzen, A., Murphy, C.A., Milne, G.T., Smythe, M.L., Carlson, K.E., PLOS ONE (2015), 10(11), 1-19. View Page

Conformational searching using a population-based incremental learning algorithm

Long, S.M., Tran, T.T., Adams, P., Darwen, P., Smythe, M.L., Journal of Computational Chemistry (2011) 32:1541-1549.

Defining scaffold geometries for interacting with proteins: geometrical classification of secondary structure linking regions

Tran, T.T., Kulis, C., Long, S.M., Bryant, D., Adams, P., Smythe, M.L., Journal Computer Aided Molecular Design (2010) Vol 24, 917-934.

Library of biphenyl privileged substructures using a safety-catch linker approach

Severinsen, R., Bourne, G.T., Tran, T.T., Ankersen, M., Begtrup, M., Smythe, M.L., Journal of Combinatorial Chemistry (2008) Vol 10, Issue 4, 557-566.

Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification

Horton, D.A., Bourne, G.T., Coughlan, J., Kaiser, S.M., Jacobs, C,M., Jones, A., Ruhmann, A., Turner, J.Y., Smythe, M.L., Organic & Biomolecular Chemistry (2008), Vol 6, Issue 8, 1386-1395.