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Presentations and Publications

A Novel Drug Discovery Platform Utilizing the Drug-Like Characteristics of Disulfide-Rich Peptides: Development of Injectable and Gastrointestinal-Stable IL-6 Antagonists
TIDES 2011, May 22-25, 2011, Hynes Convention Center and Sheraton Boston Hotel, Boston, MA.
View presentation (2.6 MB)

Conformational searching using a population-based incremental learning algorithm, Long, S.M., Tran, T.T., Adams, P., Darwen, P., Smythe, M.L., Journal of Computational Chemistry (2011) 32:1541-1549

Defining scaffold geometries for interacting with proteins: geometrical classification of secondary structure linking regions, Tran, T.T., Kulis, C., Long, S.M., Bryant, D., Adams, P., Smythe, M.L., Journal Computer Aided Molecular Design (2010) Vol 24, 917-934

Library of biphenyl privileged substructures using a safety-catch linker approach, Severinsen, R., Bourne, G.T., Tran, T.T., Ankersen, M., Begtrup, M., Smythe, M.L., Journal of Combinatorial Chemistry (2008) Vol 10, Issue 4, 557-566

Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification, Horton, D.A., Bourne, G.T., Coughlan, J., Kaiser, S.M., Jacobs, C,M., Jones, A., Ruhmann, A., Turner, J.Y., Smythe, M.L., Organic & Biomolecular Chemistry (2008), Vol 6, Issue 8, 1386-1395

The combinatorial synthesis of bicyclic privileged structures or privileged substructures, Horton, D.A., Bourne, G.T., Smythe, M.L., Chemical Reviews (2003) Vol 103, Issue 3, 893-930

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